Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 1-Benzyl-2-methyl-5-(2,4-difluorophenyl)-1H-imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2,4-Difluorophenylboronic acid | HCID 2734334 | — |
| 반응물 | 1-Benzyl-2-methyl-5-bromo-1H-imidazole | HCID 66868795 | — |
| 촉매 | Palladium(2+) acetate--triphenylphosphane (1/2/2) | HCID 84538 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 1-Benzyl-2-methyl-5-(2,4-difluorophenyl)-1H-imidazole | HCID 66869085 | 67.5% |
반응 단계
Heat a mixture of 1-benzyl-2-methyl-5-bromo-1H-imidazole (4.71 g, 18.7 mmol), 2,4-difluorophenyl boronic acid (6.92 g, 43.8 mmol), bis(acetato)bis(triphenylphosphine)-palladium(II) (1.4 g, 1.875 mmol), 2N Na2CO3 (19 mL, 38 mmol), MeOH (19 mL) and 1,2-dimethoxyethane (120 mL) to reflux for 18 h. Cool to RT. Add water and EtOAc and separate the layers. Dry organic layer over MgSO4, filter, and concentrate. Purify the residue (silica gel chromatography, eluting with EtOAc:CH2Cl2 mixtures) to give the desired compound (3.59 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582652B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-663562bcc74b4a6da309af86daf84192 |
| 출처 메모 | uspto-grants-2009_09 |