Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Furanpropionic acid → N-[1-(benzothiophen-3-yl)ethyl]-3-(2-furyl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Furanpropionic acid | HCID 70286 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | α-Methylbenzo[b]thiophene-3-methanamine | HCID 14152978 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N-[1-(benzothiophen-3-yl)ethyl]-3-(2-furyl)propionamide | HCID 68816692 | 83.9% |
반응 단계
3-(2-Furyl)propionic acid (368 mg), 1-(benzothiophen-3-yl)ethylamine (443 mg), N-ethyl-N′-dimethylaminopropylcarbodiimide hydrochloride (575 mg), 1-hydroxybenzotriazole (405 mg), and triethylamine (304 mg) were added to dehydrated dimethylformamide (DMF, 15 mL), and stirred at room temperature for 12 hours. The reaction mixture was added with water, and extracted with ethyl acetate. The organic layer was dried, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to obtain 628 mg of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582658B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-8742676b326040279d416fe2de78f1dd |
| 출처 메모 | uspto-grants-2009_09 |