4-(2-Chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione → 4-(4-Fluorophenyl)-5-(2-isopropoxypyridin-4-yl)-1,3-dihydroimidazole-2-thione

반응식

Cl.[NH2:2][CH:3]([C:13]1[CH:18]=[CH:17][N:16]=[C:15]([O:19][CH:20]([CH3:22])[CH3:21])[CH:14]=1)[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=O.ClC1C=C(C2[NH:31][C:32](=[S:42])NC=2C2C=CC(F)=CC=2)C=CN=1>>[F:12][C:9]1[CH:10]=[CH:11][C:6]([C:4]2[NH:31][C:32](=[S:42])[NH:2][C:3]=2[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([O:19][CH:20]([CH3:22])[CH3:21])[CH:14]=2)=[CH:7][CH:8]=1

참가 물질

반응물 2

HCID 108597274-(2-Chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione

HCID 690546492-Amino-1-(4-fluorophenyl)-2-(2-isopropoxypyridin-4-yl)ethanone hydrochloride

생성물 1

HCID 108604734-(4-Fluorophenyl)-5-(2-isopropoxypyridin-4-yl)-1,3-dihydroimidazole-2-thione

실험 절차

24c was prepared from 23c (2.5 g; 7.6 mmol) using the method described in the synthesis of 24a.

출처 및 근거

ORD 기록: ord-df38742bff624a119bb148051adfa229
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07582660B2

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