HCID 68950965, 화합물 → HCID 68950992, 화합물

HRID 730235노트

반응식

HRID 730235 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)=[CH:14][C:13]=2[N+:24]([O-])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[NH2:24][C:13]1[CH:14]=[C:15]([C:18]2[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=2)[CH:16]=[CH:17][C:12]=1[NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:9])=[O:10]

참가 물질

4

반응물 1

HCID 68950965HCID 68950965, 화합물

생성물 1

HCID 68950992HCID 68950992, 화합물수율 80.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4-chloro-N-(2-nitro-4-pyridin-4-ylphenyl)benzene sulfonamide (0.2 mmol) in ethyl acetate (10 mL), palladium on activated carbon (10%, wet, 10 mg) was added. The reaction mixture was deaerated under vacuum for 5 min and stirred under hydrogen atmosphere (1 atm) for 30 min. The reaction mixture was filtered through a short pad of Celite, washing the pad with methanol (10 mL) and ethyl acetate (15 mL). The combined organic phase was concentrated under vacuum to give 58 mg of N-(2-amino-4-pyridin-4-ylphenyl)-4-chlorobenzene sulfonamide.

후처리

  1. filtrationThe reaction mixture was filtered through a short pad of Celite
  2. washwashing the pad with methanol (10 mL) and ethyl acetate (15 mL)
  3. concentrationThe combined organic phase was concentrated under vacuum

출처 및 근거

ORD 기록
ord-6730f240c939469184540132f720c97f
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582673B2

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