Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzophenone → Benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzophenone | HCID 3102 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Aminoacetonitrile sulfate (1:1) | HCID 196971 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzimidazole | HCID 5798 | 156,273.703% |
반응 단계
To a stirred solution of 2-aminoacetonitrile bisulfate (2.9 g, 0.013 mmol) in dichloromethane (50 mL) was added benzophenone (3.48 mL, 0.0208 mmol) followed by DIEA (4.53 mL, 0.026 mmol). After stirring 18 h, the dichloromethane solution was washed with water (50 mL), dried over sodium sulfate, filtered, and the filtrate concentrated under reduced pressure. The residue was purified on a flash silica gel column (hexanes:EtOAc, 1:1) to give 3 (2.40 g, 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582668B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-0e81b14c40264ccfa4abbea20ac7b045 |
| 출처 메모 | uspto-grants-2009_09 |