Bromine → 2-Bromo-1-(4-iodophenyl)ethanone

HRID 730348

반응식

HRID 730348 반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[Br:11]Br>O1CCOCC1>[Br:11][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1)=[O:10]

참가 물질

4

반응물 2

HCID 24408BromineHCID 728691-(4-Iodophenyl)ethan-1-one

생성물 1

HCID 2565722-Bromo-1-(4-iodophenyl)ethanone

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 1-(4-iodophenyl)ethanone (55.9 mmol) in dioxane (160 mL) was cooled to 10° C. Bromine (1.1 equiv, 61.6 mmol) was added dropwise to the reaction mixture. After 10 min, the cooling bath was removed and the reaction mixture was stirred at room temperature. After 1.5 h, the reaction mixture was concentrated in vacuo, poured into water (100 mL), and extracted with (3×100 mL) ethyl acetate. The combined organic layers were dried over sodium sulfate and concentrated in vacuo to a tan solid (18.2 g) which was used directly in the next step.

후처리

  1. customthe cooling bath was removed
  2. waitAfter 1.5 h
  3. concentrationthe reaction mixture was concentrated in vacuo
  4. additionpoured into water (100 mL)
  5. extractionextracted with (3×100 mL) ethyl acetate
  6. dry with materialThe combined organic layers were dried over sodium sulfate
  7. concentrationconcentrated in vacuo to a tan solid (18.2 g) which

출처 및 근거

ORD 기록
ord-b0308772db1a4e8f9007e79ae1fd101b
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582668B2

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