Water → 5-Amino-1-[bis(4-fluorophenyl)methyl]-1H-pyrrole-3-carbonitrile

HRID 730432노트

반응식

HRID 730432 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:16]/[CH:17]=[C:18](\[CH2:21][C:22]#[N:23])/[C:19]#[N:20])[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[O-]CC.[K+].O>O1CCCC1.C(O)C>[NH2:23][C:22]1[N:16]([CH:8]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH:17]=[C:18]([C:19]#[N:20])[CH:21]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 23670592Potassium ethoxideHCID 69063437HCID 69063437, 화합물

생성물 1

HCID 230746485-Amino-1-[bis(4-fluorophenyl)methyl]-1H-pyrrole-3-carbonitrile

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (2E)-2-({[bis(4-fluorophenyl)methyl]amino}methylene)butanedinitrile (13.9 g, 45.1 mmol) in tetrahydrofuran (48 ml) and ethanol (48 ml) was slowly added potassium ethoxide (6.67 g, 79.2 mmol), which was stirred at room temperature for 1 hour and poured into iced water. The product was extracted with ethyl acetate, the extract was washed with water, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the objective product as oily matter.

후처리

  1. extractionThe product was extracted with ethyl acetate
  2. washthe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. customto give the objective product as oily matter

출처 및 근거

ORD 기록
ord-42a05f27fc5242338c475acdb3ce56de
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582651B2

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