Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Carbonyldiimidazole → 5-Trifluoromethyl-1,3-dihydro-benzimidazol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 4-Trifluoromethyl-1,2-phenylenediamine | HCID 520822 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Trifluoromethyl-1,3-dihydro-benzimidazol-2-one | HCID 11820150 | — |
반응 단계
A mixture of 4-trifluoromethyl-1,2-phenylenediamine (8.8 g, 50 mmol, Lancaster) and 1,1′-carbonyldiimidazole (9.0 g, 55 mmol, Aldrich) in THF (50 mL) was stirred at room temperature for 16 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography, eluting with EtOAc to give the title compound. MS (ESI, pos. ion) m/z: 203 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582761B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-04e9bb371a82400bb05f9ca6233dd47e |
| 출처 메모 | uspto-grants-2009_09 |