Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dichlorobenzimidazole → 6-Chloro-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dichlorobenzimidazole | HCID 335473 | — |
| 반응물 | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| 생성물 | 6-Chloro-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 11559986 | — |
반응 단계
The benzoimidazole from step (b) above (0.186 g, 0.995 mmol) and 1-(3-trifluoromethylpyridin-2-yl)piperazine (0.23 g, 0.995 mmol, Maybridge) reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 228-231° C. MS (ESI, pos. ion) m/z: 382 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582761B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-309798ff12574e8fa09f9c93dc320dc6 |
| 출처 메모 | uspto-grants-2009_09 |