Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-5,6-dichloro-1H-benzoimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,5,6-Trichloro-1H-benzimidazole | HCID 286009 | — |
| 반응물 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 생성물 | 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-5,6-dichloro-1H-benzoimidazole | HCID 57835109 | — |
반응 단계
The 2,5,6-trichloro-1H-benzoimidazole (0.110 g, 0.5 mmol, Example 25b), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.234 g, 1 mmol, Example 3b) and N,N-diisopropylethylamine (0.35 mL, 2 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 382 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582761B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-979f9d581a9b4054bd4faec696d3ebd4 |
| 출처 메모 | uspto-grants-2009_09 |