1,1'-Carbonyldiimidazole → 4-Nitro-6-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one

반응식

[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6]([NH2:14])[C:5]=1[NH2:15])([O-:3])=[O:2].[C:16](N1C=CN=C1)(N1C=CN=C1)=[O:17]>>[N+:1]([C:4]1[C:5]2[NH:15][C:16](=[O:17])[NH:14][C:6]=2[CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 682631,1'-Carbonyldiimidazole

HCID 50660631,2-Benzenediamine, 3-nitro-5-(trifluoromethyl)-

생성물 1

HCID 116301554-Nitro-6-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one

실험 절차

The reaction of 3-nitro-5-(trifluoromethyl)benzene-1,2-diamine (2.2 g, 10 mmol) with 1,1′-carbonyldiimidazole (1.78 g, 11 mmol, Aldrich) under the conditions of Example 1b afforded the title compound as a yellow solid. MS (ESI, pos. ion) m/z: 248 (M+1).

출처 및 근거

ORD 기록: ord-a945950ee2b24cd7beae1665faf102fc
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07582761B2

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