(R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine → HCID 178461517, 화합물

HRID 730793노트

반응식

HRID 730793 반응식
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:3]1.[Br:18][C:19]1[C:27]2[N:26]=[C:25](Cl)[NH:24][C:23]=2[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=1>>[Br:18][C:19]1[C:27]2[NH:26][C:25]([N:7]3[CH2:6][CH2:5][N:4]([C:8]4[C:13]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:11]=[CH:10][N:9]=4)[CH2:3][C@H:2]3[CH3:1])=[N:24][C:23]=2[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=1

참가 물질

3

반응물 2

HCID 11528875(R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazineHCID 115945854-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole

생성물 1

HCID 178461517HCID 178461517, 화합물

실험 절차

The piperazine from step (a) above (0.37 g, 1.5 mmol) reacted with 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.36 g, 1.2 mmol, Example 6b) under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 508 (M+1).

출처 및 근거

ORD 기록
ord-9d1479c9aa7d490fbc7f91e47b3ebaf7
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582761B2

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