2-Methylcarbamoyl-piperazine-1,4-dicarboxylic acid dibenzyl ester → N-Methylpiperazine-2-carboxamide
반응식
C(OC([N:11]1[CH2:16][CH2:15][N:14](C(OCC2C=CC=CC=2)=O)[CH2:13][CH:12]1[C:27](=[O:30])[NH:28][CH3:29])=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:29][NH:28][C:27]([CH:12]1[CH2:13][NH:14][CH2:15][CH2:16][NH:11]1)=[O:30]참가 물질
4
실험 절차
A suspension of 2-methylcarbamoyl-piperazine-1,4-dicarboxylic acid dibenzyl ester from step (b) above (1.64 g, 4.0 mmol) and 10% Pd/C (42 mg, 0.04 mmol, Aldrich) in ethanol (10 mL) was vigorously stirred under hydrogen atmosphere for 4 h at room temperature. The catalyst was filtered through Celite® pad and the filter cake was washed with EtOH. The filtrate was evaporated in vacuo to give the title compound, which was used in the next step without additional purification. MS (ESI, pos. ion) m/e: 144 (M+1).
후처리
- filtrationThe catalyst was filtered through Celite® pad
- washthe filter cake was washed with EtOH
- customThe filtrate was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-1b8325a8c6d5448ba5685f780a924e28
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07582761B2
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