Ammonium Chloride → HCID 178422616, 화합물

HRID 731064노트

반응식

HRID 731064 반응식
[CH2:1]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]3[CH:26]=[CH:25][C:20]([O:21][CH2:22][C:23]#[N:24])=[CH:19][CH:18]=3)[CH:15]=2)[N:10]([CH3:27])[C:9]=1[CH3:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:29]=[N+:30]=[N-:31].[Na+].[NH4+].[Cl-]>CN(C=O)C>[CH2:1]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]3[CH:18]=[CH:19][C:20]([O:21][CH2:22][C:23]4[NH:31][N:30]=[N:29][N:24]=4)=[CH:25][CH:26]=3)[CH:15]=2)[N:10]([CH3:27])[C:9]=1[CH3:28])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 68814337HCID 68814337, 화합물

생성물 1

HCID 178422616HCID 178422616, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The desired product was prepared using a procedure similar to step 6 of example 3. Thus, [4-(3-benzyl-1,2-dimethyl-1H-indol-5-yl)-phenoxy]-acetonitrile (0.144 g, 0.393 mmol) was reacted with NaN3 (0.128 g, 1.965 mmol) and NH4Cl (0.105 g, 1.965 mmol) in DMF (5 ml) to give the product (0.133 g, 0.325 mmol, 83%) as a white solid, dec. 214-215° C.

출처 및 근거

ORD 기록
ord-4311dd85b65d4ef9b74ce6b63912f3c1
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582773B2

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