2,3-Dichloro-5-(trifluoromethyl)pyridine → Ethyl 3-chloro-4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate

HRID 73119노트

반응식

HRID 73119 반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=1[S:25](=[O:39])(=[O:38])[NH:26][CH2:27][C:28]1[CH:29]=[C:30]2[CH:36]=[CH:35][N:34]([CH3:37])[C:31]2=[N:32][CH:33]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[Cl:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=1[S:25](=[O:38])(=[O:39])[N:26]([C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1)[CH2:27][C:28]1[CH:29]=[C:30]2[CH:36]=[CH:35][N:34]([CH3:37])[C:31]2=[N:32][CH:33]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]

참가 물질

3

반응물 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 66837935HCID 66837935, 화합물

생성물 1

HCID 66837913Ethyl 3-chloro-4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate

실험 절차

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and ethyl 3-chloro-4-(N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate (step-2 of Example 35).

출처 및 근거

ORD 기록
ord-ae8627b6dd874eb79da61783746556ef
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829026B2

반응 노트

불러오는 중…