2-Aminothiazole → N,N-Dicyclopentyl-N'-1,3-thiazol-2-ylurea

HRID 731401

반응식

HRID 731401 반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7](N1C=CN=C1)(N1C=CN=C1)=[O:8].CN(C1C=CC=CN=1)C.[CH:28]1([NH:33][CH:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[CH2:32][CH2:31][CH2:30][CH2:29]1>ClCCl.C(OCC)(=O)C>[CH:34]1([N:33]([CH:28]2[CH2:29][CH2:30][CH2:31][CH2:32]2)[C:7]([NH:1][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)=[O:8])[CH2:35][CH2:36][CH2:37][CH2:38]1

참가 물질

7

반응물 4

HCID 21552-AminothiazoleHCID 218852-DimethylaminopyridineHCID 682631,1'-CarbonyldiimidazoleHCID 247671Dicyclopentylamine

생성물 1

HCID 57688319N,N-Dicyclopentyl-N'-1,3-thiazol-2-ylurea

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and dimethylaminopyridine (3 mg) and the solution stirred 1 h at room temperature. Dicyclopentylamine (77 mg) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by flash chlomatography (eluant 7 ethyl acetate:3 heptane)

후처리

  1. stirringthe reaction stirred overnight at room temperature
  2. washwashed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
  3. dry with materialdried over magnesium sulphate
  4. concentrationconcentrated in vacuo
  5. customthe residue purified by flash chlomatography (eluant 7 ethyl acetate:3 heptane)

출처 및 근거

ORD 기록
ord-a25127cea0ca4f5ab6f9881ba3e33f5d
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582769B2

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