Butyryl chloride → Thiobutyric acid S-(1-phenyl-ethyl)ester

HRID 731503

반응식

HRID 731503 반응식
[SH:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:3].[C:10](Cl)(=[O:14])[CH2:11][CH2:12][CH3:13]>>[C:4]1([CH:2]([S:1][C:10](=[O:14])[CH2:11][CH2:12][CH3:13])[CH3:3])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 8855Butyryl chlorideHCID 1418501-Phenylethanethiol

생성물 1

HCID 86595377Thiobutyric acid S-(1-phenyl-ethyl)ester수율 98%

실험 절차

At room temperature, 13.8 g of 1-mercapto-1-phenylethane is dissolved in 50 mL of butyryl chloride. The mixture is stirred at room temperature for 6 hours. It is then cooled down to 0° C. and the reaction is quenched by careful addition of 100 ml of dry methanol in small portions. The mixture is then washed with bicarbonate, dried over magnesium sulfate, filtered and concentrated to give the butyrated compound in 98% yield.

후처리

  1. temperatureIt is then cooled down to 0° C.
  2. customthe reaction is quenched by careful addition of 100 ml of dry methanol in small portions
  3. washThe mixture is then washed with bicarbonate
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give the butyrated compound in 98% yield

출처 및 근거

ORD 기록
ord-495643dbcb4a4b69880cb975f4aba0a8
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585535B2

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