Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hexamethyldisilazide → 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzonitrile | HCID 59186611 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide | HCID 59186607 | 83.4% |
반응 단계
A solution of EXAMPLE 12A (0.515 g, 1.36 mmol) in dry tetrahydrofuran (6 mL) was treated dropwise with LiHMDS (1M, 6.8 mL, 6.8 mmol), stirred for 16 hours, quenched with 1N HCl (8 mL), and filtered. The filter cake was collected to provide the desired product (0.45 g, 71%) that was used without further purification. MS (CI) m/e 397 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07585858B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-f615de3334bf4e5d8dc073a1350c2764 |
| 출처 메모 | uspto-grants-2009_09 |