2-Amino-3-bromopyridine → 8-Bromo-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine

HRID 731611

반응식

HRID 731611 반응식
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[C:23]([Br:24])=[CH:22][CH:21]=[CH:20][N:19]=1>>[Br:24][C:23]1[C:18]2[N:19]([CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=2)[CH:20]=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 8177002-Amino-3-bromopyridineHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

생성물 1

HCID 247381838-Bromo-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine수율 48%

실험 절차

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-3-bromopyridine instead of 2-aminopyridine, to the title compound (85 mg, 48%) which was obtained as a yellow gum. MS: m/e=354.0/356.1 [M+H]+.

출처 및 근거

ORD 기록
ord-851ffaeade3146a28697920c61704384
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585874B2

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