Potassium Nitrate → 2,3-Dichloro-6-nitrobenzaldehyde

HRID 731676

반응식

HRID 731676 반응식
[N+:1]([O-:4])([O-])=[O:2].[K+].[Cl:6][C:7]1[C:14]([Cl:15])=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=[O:10]>S(=O)(=O)(O)O>[Cl:6][C:7]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:1]([O-:4])=[O:2])[C:8]=1[CH:9]=[O:10]

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 357452,3-Dichlorobenzaldehyde

생성물 1

HCID 112182712,3-Dichloro-6-nitrobenzaldehyde수율 34.5%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Potassium nitrate (578 mg, 5.71 mmol) was dissolved in concentrated sulfuric acid (4.5 mL) and added dropwise to a stirred solution of 2,3-dichlorobenzaldehyde (1.0 g, 5.71 mmol) at room temperature. The mixture was left without stirring for 10 days at room temperature. Material that had crystallized out of the reaction mixture was collected by filtration to afford 2,3-dichloro-6-nitrobenzaldehyde (196MBT36, 433 mg, 34%) as yellow needles. Regioselectivity was confirmed by the Bayer-Drewson indigo synthesis.

후처리

  1. waitThe mixture was left
  2. customMaterial that had crystallized out of the reaction mixture
  3. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-5e952184a2824600b6a45a378c0af399
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585877B2

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