Sodium Carbonate → 1-isopropyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Carbonate	HCID 10340	—
반응물	3,4-Dimethoxyphenylboronic acid	HCID 2734702	—
반응물	3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	HCID 24905337	—
촉매	HCID 178418397	HCID 178418397	—
용매	Ethanol	HCID 702	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	1-isopropyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	HCID 24905343	60%

반응 조건

온도	80 °C

반응 단계

A solution of 3,4-Dimethoxyphenylboronic acid (24 mg, 0.13 mmol) in EtOH (3.3 ml) was added to a solution of 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (20 mg, 0.07 mmol) in DME (12 ml). Pd(PPh3)4 (16 mg, 0.014 mmol) and saturated Na2CO3 (1.9 ml) were added and the reaction was heated to 80° C. under an argon atmosphere overnight. After cooling, the reaction was extracted with saturated NaCl and CH2Cl2. Organic phases were combined, concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield BA23 (13.1 mg, 60% yield). ESI-MS (M+H)+ m/z calcd 314.0, found 314.1.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07585868B2
출처 데이터셋	uspto-grants-2009_09
ORD ID	ord-2d799158ecee4b1a854b60baefdfc057
출처 메모	uspto-grants-2009_09