Ammonia methanol → 5-Iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 731879노트

반응식

Cl[C:2]1[C:3]2[C:10]([I:11])=[CH:9][N:8]([CH3:12])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH3:13].CO>>[I:11][C:10]1[C:3]2[C:2]([NH2:13])=[N:7][CH:6]=[N:5][C:4]=2[N:8]([CH3:12])[CH:9]=1

참가 물질

반응물 2

HCID 21705897Ammonia methanol

HCID 426094624-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

생성물 1

HCID 594241805-Iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

반응 조건

온도: 110 °C

실험 절차

4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (90 mg, 0.31 mmol) was taken up in 7N NH3/MeOH and heated in a sealed tube at 110° C. overnight. Reaction was concentrated in vacuo to give a brown/off-white solid.

후처리

customReaction
concentrationwas concentrated in vacuo
customto give a brown/off-white solid

출처 및 근거

ORD 기록: ord-aa7456b06db44e98adbac6086f6e75fb
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07585868B2

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