Chloroacetyl chloride → 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]benzonitrile

HRID 732011노트

반응식

HRID 732011 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([NH:8][OH:9])=[NH:7])#[N:2].C(N(CC)CC)C.[Cl:20][CH2:21][C:22](Cl)=O>ClCCl>[Cl:20][CH2:21][C:22]1[O:9][N:8]=[C:6]([C:5]2[CH:4]=[C:3]([CH:12]=[CH:11][CH:10]=2)[C:1]#[N:2])[N:7]=1

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 178509779HCID 178509779, 화합물

생성물 1

HCID 578379493-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]benzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-cyano-N-hydroxy-benzamidine (1.0 g, 6.2 mmol), triethylamine (1.5 ml, 10.6 mmol) and chloroacetyl chloride (0.74 ml, 9.3 mmol) in dichloromethane (12 ml). Purification was performed by decolorizing with silica gel. 1H NMR (CDCl3), d (ppm): 8.40 (s, 1H), 8.32 (d, 1H), 7.82 (d, 1H), 7.64 (t, 1H), 4.77 (s, 2H).

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-8fb32350b59d400b97055886c8199f4a
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585881B2

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