참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 2-Bromopropanedial | HCID 74945 | — |
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 용매 | Cyclohexane | HCID 8078 | — |
| 생성물 | 2-Bromo-3-isopropoxy-propenal | HCID 53416634 | — |
반응 단계
A mixture of 2-bromomalonaldehyde, para-toluenesulfonic acid monohydrate, 2-propanol and cyclohexane were stirred at 86° C. in flask with a dean-stark trap under azeotropic conditions. Further distillation removed another 40% of the original solvent volume. The mixture was cooled to 0° C., then concentrated in-vacuo, to isolate the title compound (13.2 g). 1H-NMR: 9.16 (s, 1H), 7.65 (s, 1H), 4.51 (m, 1H), 1.47 (d, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07585881B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_09 |
|---|
| ORD ID | ord-e8d5ea4059e54f579482ffe59c821d7e |
|---|
| 출처 메모 | uspto-grants-2009_09 |
|---|
