Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → N-(2-phenylethyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-Bromo-4'-(trifluoromethyl)acetophenone | HCID 321979 | — |
| 반응물 | (2-Phenylethyl)thiourea | HCID 735845 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(2-phenylethyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine | HCID 23143279 | 74.7% |
반응 단계
A mixture of 2-bromo-1-[4-(trifluoromethyl)phenyl]-ethanone (5.34 g), N-(2-phenylethyl)thiourea (3.60 g) and N,N-dimethylformamide (20 mL) was stirred at room temperature for 1 hr. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate and concentrated to give the title compound (5.20 g, yield 74%) as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07585880B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-ba9edc3cfea846ac9d61fddbdf795fc6 |
| 출처 메모 | uspto-grants-2009_09 |