(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester → Ethyl 3-(2,6-difluoro-4-methoxyphenyl)propanoate

HRID 732184노트

반응식

HRID 732184 반응식
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1/[CH:11]=[CH:12]/[C:13]([O:15][CH2:16][CH3:17])=[O:14]>O1CCCC1.C(O)C.[C].[Pd]>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]

참가 물질

5

반응물 1

HCID 57636644(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester

생성물 1

HCID 23082987Ethyl 3-(2,6-difluoro-4-methoxyphenyl)propanoate수율 105.5%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl(2E)-3-(2,6-difluoro-4-methoxyphenyl)acrylate (1.1 g, 4.54 mmol) was dissolved in a mixed solvent of tetrahydrofuran (30 mL) and ethanol (30 mL), 10% palladium-carbon (0.30 g) was added and the mixture was stirred under a hydrogen atmosphere at room temperature for 5 hr. The catalyst was filtered off, and the obtained filtrate was concentrated to give the title compound (1.17 g, yield 100%) as a colorless oil.

후처리

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. concentrationthe obtained filtrate was concentrated

출처 및 근거

ORD 기록
ord-847b0ebc4fe0460a8edcbc7f78928a1f
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585880B2

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