Bromine → 2-bromo-1-(4-Methoxy-Phenyl)-3-Methyl-Butan-1-One

HRID 732242노트

반응식

HRID 732242 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:14])[CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:5][CH:4]=1.[Br:15]Br>C(OC(=O)C)C>[Br:15][CH:10]([CH:11]([CH3:12])[CH3:13])[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:14]

참가 물질

4

반응물 2

HCID 24408BromineHCID 127577691-(4-Methoxyphenyl)-3-methylbutan-1-one

생성물 1

HCID 578383622-bromo-1-(4-Methoxy-Phenyl)-3-Methyl-Butan-1-One수율 96%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

While 56.9 g of 1-(4-methoxy-phenyl)-3-methyl-butan-1-one (3) prepared in Example 1 were added to 200 ml of ethylacetate and stirred, 18.2 ml of bromine were added at room temperature and stirring was continued at the same temperature for 1 hr. After the reaction was completed, the resultant reaction mixture was washed with brine and water, in that order, after which the ethylacetate layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure, thus obtaining 77.0 g (yield: 96.0%) of a title compound as light yellow liquid.

후처리

  1. stirringstirring
  2. customthe resultant reaction mixture
  3. washwas washed with brine and water, in that order
  4. dry with materialafter which the ethylacetate layer was dried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-14fbaff9b5c843eab796a9252eabdb5a
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585979B2

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