HCID 58138925, 화합물 → HCID 58138929, 화합물
반응식
[F:1][C:2]([F:16])([F:15])[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]#[N:13])=[CH:7][C:6]=2[Br:14]>C1COCC1>[F:16][C:2]([F:1])([F:15])[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([CH2:12][NH2:13])=[CH:7][C:6]=2[Br:14]참가 물질
3
실험 절차
A solution of 2-(trifluoromethyl)-5-cyano-7-bromo-1H-indole (Intermediate 4, 200 mg) in THF (10 mL) cooled in an ice-water bath was treated with borane tetrahydrofuran complex (1.52 mL) dropwise via a syringe and stirred under argon for 18 hrs while allowing to warm to room temp. The reaction mixture was then quenched with methanol (5 mL) and stirred at room temperature for 10 min. The reaction mixture was then evaporated to dryness to give the title compound as a white foam (230 mg), which was used in the next step without further purification;
후처리
- additionwas treated with borane tetrahydrofuran complex (1.52 mL) dropwise via a syringe
- customThe reaction mixture was then quenched with methanol (5 mL)
- stirringstirred at room temperature for 10 min
- customThe reaction mixture was then evaporated to dryness
출처 및 근거
- ORD 기록
- ord-01cd1980e8b54705a7a31db1c379ac08
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08829031B2
반응 노트
불러오는 중…