Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid | HCID 440074 | — |
| 생성물 | (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate | HCID 7021430 | 99% |
반응 단계
Add thionyl chloride (5.8 mL, 79.4 mmol) to an ice-cold suspension of 4-(S)-hydroxypyrrolidine-2-(R)-carboxylic acid (4.97 g, 31.9 mmol) in methanol (70 mL). Stir 10 min, then warm to room temperature and stir 3.5 h. Concentrate, add methanol and concentrate again to give the title compound as a white solid (7.18 g, 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07585885B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-e17db6fa8dcd4a458cdff2d55940ae00 |
| 출처 메모 | uspto-grants-2009_09 |