Methanol → Methyl 2-chloro-6-methoxyisonicotinate

HRID 732407

반응식

HRID 732407 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][CH3:12])[N:10]=1)[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH3:18]O>>[CH3:18][O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([O:11][CH3:12])[N:10]=[C:2]([Cl:1])[CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 27821242-Chloro-6-methoxypyridine-4-carboxylic acid

생성물 1

HCID 13339618Methyl 2-chloro-6-methoxyisonicotinate

실험 절차

Mix commercially available 2-chloro-6-methoxy-isonicotinic acid (17 g, 90.6 mmol), concentrated sulfuric acid (0.85 mL) in methanol (150 mL) and reflux overnight. Cool the mixture to room temperature, filter and dry the solid under vacuum to give the title compound (15.5 g). Concentrate filtrate and dilute with ethyl acetate (150 mL). Wash with sodium bicarbonate solution, water, dry (sodium sulfate) and concentrate to give additional title compound (1.7 g) (17.2 g, 93% combined yield).

후처리

  1. temperaturereflux overnight
  2. filtrationfilter
  3. customdry the solid under vacuum

출처 및 근거

ORD 기록
ord-54369f18103945da97ca1f5f8227fed3
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585885B2

연결된 노트

불러오는 중…