1,4-Dioxane hydrochloride → [4-(Ethoxycarbonyl)piperidin-1-yl]acetic acid
반응식
Cl.[O:2]1CCOCC1.C([C:12](=[O:25])[CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:16][CH2:15]1)(C)(C)C>O1CCOCC1>[CH2:23]([O:22][C:20]([CH:17]1[CH2:16][CH2:15][N:14]([CH2:13][C:12]([OH:25])=[O:2])[CH2:19][CH2:18]1)=[O:21])[CH3:24]참가 물질
4
반응 조건
- 온도
- 60 °C
실험 절차
At room temperature, 3.0 ml of 4 M hydrogen chloride/1,4-dioxane was added to 8 ml of 1,4-dioxane solution containing 543 mg of ethyl 1-(2-tert-butyl-2-oxoethyl)piperidine-4-carboxylate, and stirred at 60° C. for 8Hours. The thus formed solid was collected by filtration to obtain 300 mg of [4-(ethoxycarbonyl)piperidin-1-yl]acetic acid as a white solid. EP: 216.
후처리
- filtrationThe thus formed solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-a375a20b99534bbfbf58b7fa2a2e34a3
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07585886B2
반응 노트
불러오는 중…