HCID 6993579, 화합물 → HCID 68912232, 화합물

HRID 732670노트

반응식

HRID 732670 반응식
C([N:8]1[CH2:12][C@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[C@@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH2:9]1)C1C=CC=CC=1.[C:29]([O:38][CH2:39][CH3:40])(=[O:37])[CH2:30][CH2:31][CH2:32][CH2:33][C:34]([O-:36])=O>>[Si:22]([O:21][CH2:20][C@@H:10]1[C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[CH2:12][N:8]([C:34](=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][C:29]([O:38][CH2:39][CH3:40])=[O:37])[CH2:9]1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:24]

참가 물질

3

반응물 2

HCID 6993579HCID 6993579, 화합물HCID 68915124HCID 68915124, 화합물

생성물 1

HCID 68912232HCID 68912232, 화합물

실험 절차

Using the (3R,4S)-1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2-methylphenyl)pyrrolidine obtained in Reference Example 127 which is described later, the elimination of benzyl group and amidation with monoethyl adipate were carried out in that order in the same manner as in Reference Example 16 and Reference Example 50 to produce ethyl 6-[(3R,4S)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2-methylphenyl)pyrrolidin-1-yl]-6-oxohexanoate.

후처리

  1. customobtained in Reference Example 127 which

출처 및 근거

ORD 기록
ord-ea9202b22d1345b199f58b383ab33466
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07585886B2

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