2-Methoxyphenyl chloroformate → 2-Methoxyphenyl 4-(prop-2-ynyl)piperidine-1-carboxylate

HRID 732896

반응식

HRID 732896 반응식
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])=[O:3].[CH2:13]([CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)[C:14]#[CH:15]>>[CH2:13]([CH:16]1[CH2:21][CH2:20][N:19]([C:2]([O:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[O:11][CH3:12])=[O:3])[CH2:18][CH2:17]1)[C:14]#[CH:15]

참가 물질

3

반응물 2

HCID 33621432-Methoxyphenyl chloroformateHCID 18187546Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate

생성물 1

HCID 578388762-Methoxyphenyl 4-(prop-2-ynyl)piperidine-1-carboxylate

실험 절차

2-(methoxy)phenyl chloroformate (5.00 g, 26.8 mmol) was added to a solution of tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (4.60 g, 20.6 mmol) according to general procedure 1. Yield=5.03 g, 89%. m/z MH+=274.04. HPLC rt=8.7 min.

후처리

  1. customHPLC rt=8.7 min.

출처 및 근거

ORD 기록
ord-24eddad9766c4e47916aed6d0b43a8f0
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589076B2

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