2-(Tributylstannyl)furan → HCID 178508305, 화합물

HRID 732970노트

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HRID 732970 반응식
Cl[C:2]1[C:3]2[NH:11][N:10]=[N:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.C([Sn](CCCC)(CCCC)[C:17]1[O:18][CH:19]=[CH:20][CH:21]=1)CCC>CN1CCCC1=O.CCOC(C)=O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[O:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[C:2]1[C:3]2[NH:11][N:10]=[N:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1

참가 물질

6

반응물 2

HCID 43936882-(Tributylstannyl)furanHCID 178508438HCID 178508438, 화합물

생성물 1

HCID 178508305HCID 178508305, 화합물

시약·촉매·용매 3

HCID 178418476HCID 178418476, 화합물촉매HCID 8857Ethyl Acetate용매HCID 13387N-methyl-2-pyrrolidone용매

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온도
80 °C

실험 절차

A solution of 7-chloro-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine (570 mg, 3.34 mmol) in N-methyl-2-pyrrolidinone (4 mL) was treated with PdCl2(PPh3)2 (117 mg, 0.17 mmol) and 2-(tributylstannyl)furan (1.05 mL, 1 mmol), stirred at 80° C. for 5 h, diluted with EtOAc, filtered through a silica pad and concentrated in vacuo. The residue was triturated with diethyl ether and the title compound isolated as a yellow solid (438 mg, 65%).

후처리

  1. filtrationfiltered through a silica pad
  2. concentrationconcentrated in vacuo
  3. customThe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-8c486eda2bcf47cd9bca716ec4ab4568
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589097B2

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