3-Chloroaniline → HCID 21874542, 화합물

HRID 732984노트

반응식

HRID 732984 반응식
[NH2:1][C:2]1[N:3]=[C:4]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]([OH:14])=O)[C:6]=2[N:7]=1.C(C1NC=CN=1)(C1NC=CN=1)=O.[Cl:32][C:33]1[CH:34]=[C:35]([CH:37]=[CH:38][CH:39]=1)[NH2:36]>CN(C=O)C.O>[NH2:1][C:2]1[N:3]=[C:4]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]([NH:36][C:35]3[CH:37]=[CH:38][CH:39]=[C:33]([Cl:32])[CH:34]=3)=[O:14])[C:6]=2[N:7]=1

참가 물질

6

반응물 3

HCID 79323-ChloroanilineHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 9813851HCID 9813851, 화합물

생성물 1

HCID 21874542HCID 21874542, 화합물수율 50.8%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A suspension of (5-amino-7-(2-furyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)acetic acid (140 mg, 0.5 mmol) in DMF (1 mL) was treated with carbonyl diimidazole (81 mg, 0.5 mmol), stirred at room temperature for 1 h, treated with 3-chloroaniline (53 μL, 0.5 mmol) and the mixture heated to 50° C. for 16 h. The reaction mixture was cooled, diluted with water (3 mL) and filtered to give the title compound (94 mg, 48%) as a cream solid.

후처리

  1. temperaturethe mixture heated to 50° C. for 16 h
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-dd7136eefdd74b54a5f0f8b0198f814b
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589097B2

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