Dimethylamine → HCID 178508306, 화합물

HRID 733012노트

반응식

HRID 733012 반응식
[NH2:1][C:2]1[N:3]=[C:4]([C:28]2[O:29][CH:30]=[CH:31][CH:32]=2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:27]=[CH:26][C:15]4[N:16](C(OC(C)(C)C)=O)[N:17]=[N:18][C:14]=4[CH:13]=3)[C:6]=2[N:7]=1.C1COCC1.CNC>CO>[NH:16]1[C:15]2[CH:26]=[CH:27][C:12]([CH2:11][N:8]3[C:6]4[N:7]=[C:2]([NH2:1])[N:3]=[C:4]([C:28]5[O:29][CH:30]=[CH:31][CH:32]=5)[C:5]=4[N:10]=[N:9]3)=[CH:13][C:14]=2[N:18]=[N:17]1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 21874651HCID 21874651, 화합물

생성물 1

HCID 178508306HCID 178508306, 화합물수율 30%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of tert-butyl 5-(5-amino-7-(2-furyl)-3H-triazolo[4,5-d]pyrimidin-3-yl)methyl-1H-benzotriazol-1-carboxylate (as a mixture with the 6-substituted regioisomer) (135 mg, 0.31 mmol) in MeOH (5 mL) and THF (5 mL) was treated with 40% aqueous dimethylamine (0.176 mL, 1.56 mmol), refluxed for 25 min, concentrated in vacuo and the resulting solid triturated with ether, filtered, triturated with MeOH, filtered and dried to give the title compound (31 mg, 30%) as a yellow solid.

후처리

  1. temperaturerefluxed for 25 min
  2. concentrationconcentrated in vacuo
  3. customthe resulting solid triturated with ether
  4. filtrationfiltered
  5. customtriturated with MeOH
  6. filtrationfiltered
  7. customdried

출처 및 근거

ORD 기록
ord-ef1b162935b34b19b770ebbe781a7e63
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589097B2

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