참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 6-Fluoroindole-3-carboxaldehyde | HCID 262903 | — |
| 반응물 | Sodium Formate | HCID 2723810 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 생성물 | 6-Fluoro-1H-indole-3-carbonitrile | HCID 53418730 | 59.9% |
반응 단계
To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08829040B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-111bd519c84a4f52ada23e687209d777 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
