Hydroxylamine → 6-Fluoro-1H-indole-3-carbonitrile

HRID 73322

반응식

HRID 73322 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=O)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[NH2:13]O.C([O-])=O.[Na+].O>C(O)=O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:13])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 787HydroxylamineHCID 962WaterHCID 2629036-Fluoroindole-3-carboxaldehydeHCID 2723810Sodium Formate

생성물 1

HCID 534187306-Fluoro-1H-indole-3-carbonitrile수율 59.9%

시약·촉매·용매 1

HCID 284Formic Acid용매

반응 조건

온도
100 °C

실험 절차

To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).

후처리

  1. temperatureAfter cooling to ambient temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-111bd519c84a4f52ada23e687209d777
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829040B2

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