Chlorosulfonic acid → HCID 17856313, 화합물

HRID 733366노트

반응식

HRID 733366 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]([F:23])([F:22])[C:8]([NH:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][CH:14]=1)=[O:9]>O>[CH:19]([C:16]1[CH:17]=[CH:18][C:13]([CH2:12][CH2:11][NH:10][C:8](=[O:9])[C:7]([F:22])([F:23])[F:6])=[C:14]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:15]=1)([CH3:21])[CH3:20]

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 184569342,2,2-Trifluoro-N-[2-[4-(1-methylethyl)phenyl]ethyl]acetamide

생성물 1

HCID 17856313HCID 17856313, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Chlorosulfonic acid (2.05 mL) was added to 1.6 g of 2,2,2-trifluoro-N-[2-(4-isopropylphenyl)ethyl]acetamide, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice-water, and water was added to the mixture. The mixture was extracted with ethyl acetate, and the organic layer was washed with brine, and dried over an hydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: ethyl acetate-hexane) to give 0.463 g of 5-isopropyl-2-[2-(2,2,2-trifluoroacetyl-amino)ethyl]benzenesulfonyl chloride.

후처리

  1. additionwas added to the mixture
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe organic layer was washed with brine
  4. dry with materialdried over an hydrous magnesium sulfate
  5. customThe solvent was removed under reduced pressure
  6. customthe residue was purified by column chromatography on silica gel (eluent: ethyl acetate-hexane)

출처 및 근거

ORD 기록
ord-ec9ea5e8aa37431fb0323f8cba642750
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589126B2

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