Octanoic acid, 2-(2-propynyl)-, (2R)- → (R)-(-)-2-propyloctanoic acid

HRID 733490

반응식

HRID 733490 반응식
[CH:1]([Mg]Cl)=[CH2:2].C([Mg]Br)=C.C([Mg]Cl)#C.C([Mg]Br)#C.C=CC[C@H](O)CCCCCC.C#CC[C@H](O)CCCCCC.[CH2:39]([C@@H:42]([CH2:46][CH2:47][CH2:48][CH2:49]CC)[C:43]([OH:45])=[O:44])[CH:40]=[CH2:41].C([C@@H](CCCCCC)C(O)=O)C#C>>[CH2:39]([C@H:42]([CH2:46][CH2:47][CH2:48][CH2:49][CH2:1][CH3:2])[C:43]([OH:45])=[O:44])[CH2:40][CH3:41]

참가 물질

9

반응물 8

HCID 10130241Octanoic acid, 2-(2-propynyl)-, (2R)-HCID 10313415(2r)-(2-Propenyl)octanoic acidHCID 11084130(4r)-1-Decen-4-olHCID 13357604(4r)-1-Decyn-4-olHCID 178418486HCID 178418486, 화합물HCID 178418507HCID 178418507, 화합물HCID 178461836HCID 178461836, 화합물HCID 178462451HCID 178462451, 화합물

생성물 1

HCID 208925(R)-(-)-2-propyloctanoic acid

실험 절차

Additionally, it is also possible in the above reaction steps that, for example, in the step (A), a two-carbon adding reaction is carried out using an unsaturated organic metal reagent (e.g., vinyl magnesium chloride, vinyl magnesium bromide, ethynyl magnesium chloride, ethynyl magnesium bromide, etc.) as an organic metal reagent, the resulting (4R)-1-decen-4-ol or (4R)-1-decyn-4-ol is subjected to the reactions of the step (B) or the step (C), and the resulting (2R)-(2-propenyl)octanoic acid or (2R)-(2-propynyl)octanoic acid is reduced by the method mentioned in WO 99/58513 and WO 00/48982 to give (2R)-2-propyloctanoic acid of high purity.

후처리

  1. customAdditionally, it is also possible in the above reaction steps that, for example
  2. customin the step (A), a two-carbon adding reaction

출처 및 근거

ORD 기록
ord-757fc3931192425eb10714e26e3e193e
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07589221B2

연결된 노트

불러오는 중…