2-Chloro-5-iodo-3-nitropyridine → 7-Chloro-4-iodo-3-methyl-1H-pyrrolo[2,3-c]pyridine

To a solution of 1-propenylmagnesium bromide (0.5M solution in tetrahydrofuran, 264 ml) at 0° C. under nitrogen was added a solution of 2-chloro-5-iodo-3-nitro-pyridine (11 g) in dry tetrahydrofuran (225 ml), dropwise over 45 minutes. After 10 minutes at 0° C. the reaction was quenched with saturated ammonium chloride (300 ml). The mixture was then extracted with ethyl acetate (300 ml) which was dried over magnesium sulphate, filtered and evaporated to give a red oily solid. The residue was triturated with diethyl ether and refrigerated over night. The solid was then filtered onto a sinter, sucked dry then dried at 60° C. under vacuum to afford the title compound (3.27 g). The filtrate was evaporated, dissolved in the minimum of diethyl ether and seeded with the above, refrigerated overnight, filtered and dried under vacuum at 60° C. to afford a further crop (345 mg).

1. customAfter 10 minutes at 0° C. the reaction was quenched with saturated ammonium chloride (300 ml)
2. extractionThe mixture was then extracted with ethyl acetate (300 ml) which
3. dry with materialwas dried over magnesium sulphate
4. filtrationfiltered
5. customevaporated
6. customto give a red oily solid
7. customThe residue was triturated with diethyl ether
8. waitrefrigerated over night
9. filtrationThe solid was then filtered onto a sinter
10. customsucked dry
11. customthen dried at 60° C. under vacuum

ORD 기록

ord-2a730703883f4752927f5423224afac6

출처 데이터셋

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07589206B2