Sodium t-butoxide → Methyl 4,5-dihydro-1-methyl-4-oxo-1H-pyrrolo[3,2-C]pyridine-7-carboxylate
반응식
[NH2:1][CH:2]=[C:3]([C:8]1[N:9]([CH3:17])[CH:10]=[CH:11][C:12]=1[C:13](OC)=[O:14])[C:4]([O:6][CH3:7])=[O:5].CC(C)([O-])C.[Na+]>CN(C)C=O>[CH3:17][N:9]1[C:8]2[C:3]([C:4]([O:6][CH3:7])=[O:5])=[CH:2][NH:1][C:13](=[O:14])[C:12]=2[CH:11]=[CH:10]1참가 물질
4
실험 절차
A mixture of methyl 2-{2-amino-1-[(methyloxy)carbonyl]ethenyl}-1-methyl-1H-pyrrole-3-carboxylate (2 g) and sodium t-butoxide (160 mg) in dimethylformamide (18 ml) was irradiated within a microwave reactor at 160° C. for 20 minutes. The reaction was repeated 28 times. The reaction mixtures were combined (56.4 g) and after cooling a precipitate formed which was filtered, washed with water and dried in vacuo to yield the title compound (17.1 g).
후처리
- customwas irradiated within a microwave reactor at 160° C. for 20 minutes
- customThe reaction mixtures
- temperatureafter cooling a precipitate
- customformed which
- filtrationwas filtered
- washwashed with water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-702b650eb40043e0b3ea0d7a55ee5ec9
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07589206B2
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