참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Ethyl 3-iodobenzoate | HCID 143542 | — |
| 반응물 | 3-Cyanoindole | HCID 230282 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3-(3-Cyanoindol-1-yl)benzoic acid ethyl ester | HCID 58437417 | 66.5% |
반응 단계
To a solution of 1H-indole-3-carbonitrile (0.28 g) in dimethyl sulfoxide (3 mL) were added 3-iodobenzoic acid ethyl ester (0.61 g), cesium carbonate (0.65 g), copper iodide (0.038 g) and N,N-dimethyl grycine (0.041 g), this mixture was stirred at 75° C. for 3 days. To this reaction mixture was added ethyl acetate, the insoluble material was removed by filtration and this filtrate was concentrated under reduced pressure. To this residue was added water, the precipitated solid was collected by filtration, and washed with water and n-hexane, and dried under reduced pressure at 40° C. to give the title compound (0.38 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08829040B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-61e47699cfcb4f298d9b227daeab03f2 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
