N-[5-amino-2-(4-methylpiperazin-1-yl)phenyl]acetamide → HCID 127045531, 화합물

온도

150 °C

In a 40mL vial (t=g) was 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (80 mg, 0.34 mmol), [Reactants], and cesium carbonate (145 mg, 0.45 mmol) in DMA (0.5 mL) ([VOLUME]),Pd2(dba)3 (15.68 mg, 0.02 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (19.81 mg, 0.03 mmol) were added. to give a brown suspension. The vial was filled with N2, 150C microwave for 30 min. LCMS showed completion. concentrated. loaded on ISCO (Hex to Hex:EtOAc To EtOAc:MeOH=10:1 to EtOAc:MeOH:Et3N=10:1:0.1) to give yellow solid. This yellow solid was washed with EtOAc(1mL) to give 40mg pure compound. NMR, 1H,HPLC are OK, see attachment

ORD 기록

ord-a86dba2ccd9142e390883516f628700c

출처 데이터셋

750 AstraZeneca ELN dataset

원본 링크

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