Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-5-chlorothiophene-2-sulfonyl chloride → 4-Bromo-5-chloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-2-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-5-chlorothiophene-2-sulfonyl chloride | HCID 2797220 | — |
| 반응물 | 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine | HCID 59386306 | — |
| 생성물 | 4-Bromo-5-chloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-2-sulfonamide | HCID 56953232 | — |
반응 단계
According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene1,2-diamine was reacted with 4-bromo-5-chlorothiophene-2-sulfonyl chloride to obtain the title compound. 1H NMR (300 MHz, CDCl3): δ7.42-7.34 (m, 2H), 7.25 (br m, 3H), 7.13 (dd, J=9.0 & 17.1 Hz, 1H), 6.02 (dt, J=2.4, 6.6 & 17.4 Hz, 1H), 5.52 (br s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829052B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3bbf35bf46f148f3b30834774d8f48ff |
| 출처 메모 | uspto-grants-2014_09 |