2-Aminooctadecane-1,3-diol → 2-(4-Nitrophenylamino)octadecane-1,3-diol

HRID 734145

반응식

HRID 734145 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH2:11][CH:12]([CH:15]([OH:31])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:13][OH:14].C(=O)([O-])[O-].[Na+].[Na+]>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:11][CH:12]([CH:15]([OH:31])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:13][OH:14])=[CH:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 31262-Aminooctadecane-1,3-diolHCID 9590p-FluoronitrobenzeneHCID 10340Sodium Carbonate

생성물 1

HCID 231045982-(4-Nitrophenylamino)octadecane-1,3-diol수율 25.7%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

13 g (0.092 mol) of 4-fluoronitrobenzene, 30 g (0.099 mol) of 2-aminooctadecane-1,3-diol and 11 g (0.104 mol) of sodium carbonate were introduced into a 250 ml reactor equipped with a condenser. The reaction mixture was maintained at 120° C. for 3 hours. 200 ml of water were added slowly to the reaction medium, which was then poured into 500 ml of ice-cold water. The precipitate formed was filtered off on a sinter funnel and dried under vacuum at 50° C. in the presence of P2O5. After recrystallization twice from ethanol, 10 g of yellow powder were isolated.

후처리

  1. customequipped with a condenser
  2. customThe precipitate formed
  3. filtrationwas filtered off on a sinter funnel
  4. dry with materialdried under vacuum at 50° C. in the presence of P2O5
  5. customAfter recrystallization twice from ethanol

출처 및 근거

ORD 기록
ord-dd0c023ec5b942569b157ab545911817
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07591860B2

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