tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline → (S)-4,4-dimethylpyrrolidine-2-carboxylic acid

반응식

C([C@@:5]1([C:19]([OH:21])=[O:20])[CH2:9][C:8]([CH3:11])([CH3:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)(C)(C)C>ClCCl>[CH3:10][C:8]1([CH3:11])[CH2:7][NH:6][C@H:5]([C:19]([OH:21])=[O:20])[CH2:9]1

참가 물질

실험 절차

A solution of tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline in dichloromethane (5 mL) and trifluoroacetic (5 mL) was stirred at room temperature for five hours. The solution was concentrated, dried under high vacuum and taken to the next step without further purification.

후처리

concentrationThe solution was concentrated
customdried under high vacuum
customtaken to the next step without further purification

출처 및 근거

ORD 기록: ord-4f3358791a2444a5ab857605c23461e2
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07592316B2

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참가 물질

반응물 1

HCID 67158944tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline

생성물 1

HCID 46907953(S)-4,4-dimethylpyrrolidine-2-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

후처리

concentrationThe solution was concentrated
customdried under high vacuum
customtaken to the next step without further purification

출처 및 근거

ORD 기록: ord-4f3358791a2444a5ab857605c23461e2
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07592316B2

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불러오는 중…