Acetone → HCID 68815972, 화합물

HRID 734322노트

반응식

HRID 734322 반응식
[CH:1]([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH3:19][C:20]([CH3:22])=[O:21].[C:23](O[BH-](OC(=O)C)OC(=O)C)(=[O:25])C.[Na+].[CH2:37](Cl)Cl>>[CH:1]([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([CH:13]2[CH2:14][CH2:15][N:16]([C:23]([O:21][C:20]([CH3:37])([CH3:22])[CH3:19])=[O:25])[CH2:17][CH2:18]2)=[O:12])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

참가 물질

5

반응물 4

HCID 180AcetoneHCID 6344DichloromethaneHCID 5049666Sodium triacetoxyborohydrideHCID 11550595AG-H-20408

생성물 1

HCID 68815972HCID 68815972, 화합물

실험 절차

The product of D8, Step 2 (2.0 g) was dissolved in DCM (50 ml) and acetone (0.94 ml) added and the mixture stirred for 5 min. Sodium triacetoxyborohydride (2.7 g) was then added and the reaction stirred at rt for 1.5 h. The reaction mixture was then washed with saturated potassium carbonate solution (50 ml), sodium hydrogen carbonate solution (3×50 ml) and brine (50 ml). The organic layer was dried (MgSO4) and evaporated to give the subtitled compound as a white solid (1.50 g).

후처리

  1. stirringthe reaction stirred at rt for 1.5 h
  2. washThe reaction mixture was then washed with saturated potassium carbonate solution (50 ml), sodium hydrogen carbonate solution (3×50 ml) and brine (50 ml)
  3. dry with materialThe organic layer was dried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-4355d4a6639e41e09905cb4ab546c64d
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592347B2

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