Thietane oxide → HCID 69072849, 화합물

HRID 734370노트

반응식

HRID 734370 반응식
[C:1]([CH2:4][O:5][CH2:6][C:7]([N:9]([CH3:27])[C:10]1[CH:26]=[CH:25][C:13]2[N+:14](CCCS([O-])(=O)=O)=[C:15]([CH3:17])[S:16][C:12]=2[CH:11]=1)=[O:8])([OH:3])=[O:2].C1CS(=O)C1>C(#N)C>[CH3:27][N:9]([C:10]1[CH:26]=[CH:25][C:13]2[N:14]=[C:15]([CH3:17])[S:16][C:12]=2[CH:11]=1)[C:7](=[O:8])[CH2:6][O:5][CH2:4][C:1]([OH:3])=[O:2]

참가 물질

4

반응물 2

HCID 25747Thietane oxideHCID 86602956HCID 86602956, 화합물

생성물 1

HCID 69072849HCID 69072849, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3-{5-[[(Carboxymethoxy)acetyl](methyl)amino]-2,3,3-trimethyl-3H-indolium-1-yl}propane-1-sulfonate (22) and 3-{6-[[(Carboxymethoxy) acetyl](methyl)amino]-2-methyl-1,3-benzothiazol-3-ium-3-yl}propane-1-sulfonate (23). To a solution of acid (21 or 22, 1.00 mmol) in 25 mL of dry acetonitrile was added propane sulfone (10 mmol). This mixture was stirred under reflux for 48 h. After cooling the hygroscopic salt was filtered, washed with acetone, and immediately used in the next step.

후처리

  1. temperatureunder reflux for 48 h
  2. temperatureAfter cooling the hygroscopic salt
  3. filtrationwas filtered
  4. washwashed with acetone

출처 및 근거

ORD 기록
ord-74cacc383c31437bb5af66a8e87024a3
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592188B2

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