Acetic Acid → HCID 12477793, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:13])[CH2:11][Cl:12].[C:14](O)(=[O:16])[CH3:15]>>[Cl:12][CH2:11][C:10]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=1[NH:1][C:14](=[O:16])[CH3:15])=[O:13]

참가 물질

반응물 2

HCID 176Acetic Acid

HCID 12477785Ethanone, 1-(2-amino-4-methoxyphenyl)-2-chloro-

생성물 1

HCID 12477793HCID 12477793, 화합물수율 100%

실험 절차

A solution of 1-(2-amino-4-methoxyphenyl)-2-chloroethanone (9.93 g, 49.74 mmol) (Example 10) in acetic acid (100 mL) was heated at 85° C. for 4 h. The solvent was evaporated under reduced pressure to yield a yellow solid (12.00 g, 100%). LC/MS m/z 242 (M+H)+; 1H NMR (400 MHz, DMSO-d6) δ 11.77 (s, 1H), 8.45 (d, 1H), 7.73 (d, 1H), 6.63 (dd, 1H), 4.71 (s, 2H), 3.89 (s, 3H), 2.25 (s, 3H).

후처리

customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록: ord-cc5f9b7c67c249c09f840b0cf45220c3
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07592361B2

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